Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/23719

TitleChitosan membranes containing micro or nano-size bioactive glass particles : evolution of biomineralization followed by in-situ dynamic mechanical analysis
Author(s)Caridade, S. G.
Merino, Esther G.
Alves, N. M.
Zea Bermudez, V. de
Boccaccini, A. R.
Mano, J. F.
KeywordsBioactive glass
Bioactivity
Bone regeneration.
Dynamic mechanical analysis
Nanocomposites
Issue date2013
PublisherElsevier
JournalJournal of the Mechanical Behavior of Biomedical Materials
Abstract(s)A newfamilyofbiodegradablepolymer/bioactiveglass(BG)compositematerialshas emergedbasedontheavailabilityofnano-sizedbioactiveparticles.Suchnovelbiocompo- sites canhaveenhancedperformance,intermsofmechanicalpropertiesandbioactivity, and theycanbedesignedtobeusedinboneregenerationapproaches. In thiswork,membranesofchitosan(CTS)andchitosanwithbioactiveglass(BG)both micron andnanosizedparticles(CTS/mBG,CTS/nBG,respectively)werepreparedby solvent casting.Microstructuralandmechanicalpropertieswereevaluatedinorderto compare theeffectsoftheincorporationofmicro(mBG) andnano(nBG)particlesinthe chitosan matrix. In vitro bioactivity testswereperformedtocharacterizetheapatitelayer that isformedonthesurfaceofthematerialafterbeingimmersedinsimulatedbodyfluid (SBF). Thebiomineralizationprocessonthebiomaterialswasalsofollowedusingnon- conventionaldynamicmechanicalanalysis(DMA),bothonlineandoffline.InsuchDMA experiments,thechangeinthestoragemodulus, E0, andthelossfactor,tan d, were measured asafunctionoftheimmersiontimeinSBF.TheresultsdemonstratedthatCTS/ nBG membranespossessenhancedmechanicalpropertiesandhigherbioactivityin comparisonwiththeCTS/mBG membranes.SuchresultssuggestthepotentialofnBGfor the developmentofbioactivecompositesforboneregenerationapplications.
TypeArticle
URIhttp://hdl.handle.net/1822/23719
DOI10.1016/j.jmbbm.2012.11.012
ISSN1751-6161
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S1751616112003244
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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