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http://hdl.handle.net/1822/23719| Title: | Chitosan membranes containing micro or nano-size bioactive glass particles : evolution of biomineralization followed by in-situ dynamic mechanical analysis |
| Author(s): | Caridade, S. G. Merino, Esther G. Alves, N. M. Zea Bermudez, V. de Boccaccini, A. R. Mano, J. F. |
| Keywords: | Bioactive glass Bioactivity Bone regeneration. Dynamic mechanical analysis Nanocomposites |
| Issue date: | 2013 |
| Publisher: | Elsevier |
| Journal: | Journal of the Mechanical Behavior of Biomedical Materials |
| Abstract(s): | A newfamilyofbiodegradablepolymer/bioactiveglass(BG)compositematerialshas emergedbasedontheavailabilityofnano-sizedbioactiveparticles.Suchnovelbiocompo- sites canhaveenhancedperformance,intermsofmechanicalpropertiesandbioactivity, and theycanbedesignedtobeusedinboneregenerationapproaches. In thiswork,membranesofchitosan(CTS)andchitosanwithbioactiveglass(BG)both micron andnanosizedparticles(CTS/mBG,CTS/nBG,respectively)werepreparedby solvent casting.Microstructuralandmechanicalpropertieswereevaluatedinorderto compare theeffectsoftheincorporationofmicro(mBG) andnano(nBG)particlesinthe chitosan matrix. In vitro bioactivity testswereperformedtocharacterizetheapatitelayer that isformedonthesurfaceofthematerialafterbeingimmersedinsimulatedbodyfluid (SBF). Thebiomineralizationprocessonthebiomaterialswasalsofollowedusingnon- conventionaldynamicmechanicalanalysis(DMA),bothonlineandoffline.InsuchDMA experiments,thechangeinthestoragemodulus, E0, andthelossfactor,tan d, were measured asafunctionoftheimmersiontimeinSBF.TheresultsdemonstratedthatCTS/ nBG membranespossessenhancedmechanicalpropertiesandhigherbioactivityin comparisonwiththeCTS/mBG membranes.SuchresultssuggestthepotentialofnBGfor the developmentofbioactivecompositesforboneregenerationapplications. |
| Type: | Article |
| URI: | http://hdl.handle.net/1822/23719 |
| DOI: | 10.1016/j.jmbbm.2012.11.012 |
| ISSN: | 1751-6161 |
| Publisher version: | http://www.sciencedirect.com/science/article/pii/S1751616112003244 |
| Peer-Reviewed: | yes |
| Access: | Open access |
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Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 17457-Caridade SG et al_JMBBM.pdf | 1,32 MB | Adobe PDF | View/Open |
