Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/23132

TítuloHydrogels for nucleus replacement : facing a biomechanical challenge
Autor(es)Reitmaier, S.
Wolfram, U.
Ignatius, A.
Wilke, H. - J.
Gloria, A.
Martín-Martínez, José M.
Correia, Joana Silva
Oliveira, Joaquim M.
Reis, R. L.
Schmidt, H.
Palavras-chaveCompression test
Disc regeneration
Hydrogels
In vitro
In vivo
intervertebral disc
Nucleus replacement
DataOut-2012
RevistaJournal of the Mechanical Behavior of Biomedical Materials
Resumo(s)Hydrogelsareconsideredpromisingfordiscregenerationstrategies.However,itiscurrently unknownwhetherthedestructionofthenaturalinterfacebetweennucleusandsurrounding structurescausedbynucleotomyandaninadequateannulusclosurediminishesthemechan- ical competenceofthedisc.This in vitro studyaimedtoclarifythesemechanismsandto evaluatewhetherhydrogelsareabletorestorethebiomechanicalbehaviourofthedisc. Nucleuspressureinanovineintervertebraldiscwasmeasured in vivo during dayandnightandadaptedtoan in vitro axial compressivediurnal(15min)andnight(30min) load. Effectsofdifferentdefectsondischeight andnucleuspressureweresubsequently measured in vitro using 30ovinemotionsegments.Followingcaseswereconsidered:intact; annulusincisionrepairedbysutureandglue;annulusincisionwithremovalandre-implanta- tion ofnucleustissue;andtwodifferenthydrogelsrepairedbysutureandglue. Theintradiscalpressure in vivo was0.75MPaduringdayand0.5MPaduringnight correspondingtoan in vitro axial compressiveforceof130and58N,respectively.The compressiontestshowedthatneithertheimplantation ofhydrogelsnorthere-implantation of thenaturalnucleus,assumedasbeingtheidealimplant,wasabletorestorethemechanical functionalityofanintactdisc. Resultsindicatetheimportanceofthenaturalanchorageofthenucleuswithitssurround- ingstructuresandtherelevanceofanappropriateannulusclosure.Therefore,hydrogelsthat areabletomimicthemechanicalbehaviourofthenativenucleusmayfailinrestoringthe mechanicalbehaviourofthedisc.
Tipoarticle
URIhttp://hdl.handle.net/1822/23132
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
1349168797_Reitmaier et al 2012_JMechBehavBiomedMater.pdf1,55 MBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis