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TitleEnhanced proliferation of pre-osteoblastic cells by dynamic piezoelectric stimulation
Author(s)Ribeiro, C.
Moreira, Susana Margarida Gomes
Correia, Vítor
Sencadas, Vítor João Gomes Silva
Rocha, J. G.
Gama, F. M.
Gómez Ribelles, J. L.
Lanceros-Méndez, S.
Issue date2012
PublisherRoyal Society of Chemistry
JournalRSC Advances
Abstract(s)This work reports on the influence of the polarization of electroactive poly(vinylidene fluoride), PVDF, on the biological response of cells cultivated under static and dynamic conditions. Non-poled and "poled +" β-PVDF with and without titanium layer were thus prepared. Thin titanium layer was deposited on PVDF films in order to get a more homogeneous surface charge. MC3T3-E1 osteoblast cell culture 10 exhibited different responses in the presence of PVDF films. The positively charged β-PVDF films promote higher osteoblast adhesion and proliferation, which is higher under dynamic conditions on poled samples, showing that the surface charge under mechanical stimulation improves the osteoblast growth. Therefore, electroactive membranes and scaffolds can provide the necessary electrical stimuli for the growth and proliferation of specific cells.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CAlg - Artigos em revistas internacionais/Papers in international journals
CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FCD - Artigos/Papers (with refereeing)

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