Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22752
Título: | From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering |
Autor(es): | Santo, Vitor E. Gomes, Manuela E. Mano, J. F. Reis, R. L. |
Palavras-chave: | bone regeneration cartilage regeneration controlled release gradients growth factors intracellular delivery layer-by-layer regenerative medicine self-assembly tissue engineering layer-by-layer regenerative medicine |
Data: | 2012 |
Editora: | Future Medicine Ltd |
Revista: | Nanomedicine |
Resumo(s): | The field of biomaterials has advanced towards the molecular and nanoscale design of bioactive systems for tissue engineering, regenerative medicine and drug delivery. Spatial cues are displayed in the 3D extracellular matrix and can include signaling gradients, such as those observed during chemotaxis. Architectures range from the nanometer to the centimeter length scales as exemplified by extracellular matrix fibers, cells and macroscopic shapes. The main focus of this review is the application of a biomimetic approach by the combination of architectural cues, obtained through the application of micro- and nanofabrication techniques, with the ability to sequester and release growth factors and other bioactive agents in a spatiotemporal controlled manner for bone and cartilage engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22752 |
DOI: | 10.2217/NNM.12.78 |
ISSN: | 1743-5889 |
e-ISSN: | 1748-6963 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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VESanto_Nanomedicine12.pdf Acesso restrito! | 2,44 MB | Adobe PDF | Ver/Abrir |