Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22717
Título: | A software tool for the simulation and optimization of dynamic metabolic models |
Autor(es): | Evangelista, Pedro Rocha, I. Ferreira, Eugénio C. Rocha, Miguel |
Data: | 2009 |
Editora: | Springer Verlag |
Revista: | Lecture Notes in Computer Science |
Resumo(s): | In Systems Biology, there is a growing need for simulation and optimization tools for the prediction of the phenotypical behavior of microorganisms. In this paper, an open-source software platform is proposed to provide support for research in Metabolic Engineering, by implementing tools that enable the simulation and optimization of dynamic metabolic models using ordinary differential equations. Its main functionalities are related with (i) phenotype simulation of both wild type and mutant strains under given environmental conditions and (ii) strain optimization tackling tasks such as gene knockout selection or the definition of the optimal level of enzyme expression, given appropriate objective functions. The central carbon metabolism of E. coli was used as a case study, to illustrate the main features of the software. |
Tipo: | Artigo em ata de conferência |
URI: | https://hdl.handle.net/1822/22717 |
ISBN: | 9783642024801 |
DOI: | 10.1007/978-3-642-02481-8_162 |
ISSN: | 0302-9743 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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IWAPCBB2009-1071.pdf | 728,98 kB | Adobe PDF | Ver/Abrir |