Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22685
Título: | Synthesis of novel psoralen analogues and in vitro antitumor activity |
Autor(es): | Francisco, Carla Santana Rodrigues, L. R. Cerqueira, N. M. F. S. A. Campos, Ana M. F. Oliveira Rodrigues, Lígia M. |
Palavras-chave: | Psoralen Antitumour activity Oxopyranocarbazole |
Data: | 2012 |
Resumo(s): | Psoralens are natural products present in several plant families that are extremely toxic to a wide variety of prokaryotic and eukaryotic organisms. They are potentially active in diseases such as vitiligo, psoriasis, and several types of cancer. Following our interest on this type of compounds 1 four new psoralen analogues were prepared, 1a-1c and 1e. To synthesize 1a (R = H) the method of Harayama and Ishii was used where the cinnamate was obtained by the Wittig reaction followed by ring closure. Condensation of 1-formyl-2-hydroxycarbazole with diethyl malonate gave 1b which by basic hydrolysis yielded compound 1c. Compound 1d was prepared before.2 Condensation of the 2-hydroxycarbazole with ethyl acetoacetate gave 1e. The products were characterized by elemental analysis, 1H and 13C NMR. Moreover, the anti-proliferative effect of compounds 1a-1e on human cancer cell lines (MDA-MB 231, HeLa and TCCSUP) was evaluated. Results suggest that these psoralen analogues possess a potent cytotoxic effect against the cell lines studied. Computational and molecular docking studies are being carried out. |
Tipo: | Resumo em ata de conferência |
URI: | https://hdl.handle.net/1822/22685 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Comunicações e Proceedings |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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TET SYMP 13.pdf | Documento principal | 27,48 kB | Adobe PDF | Ver/Abrir |