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TitleSynthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors
Author(s)Peixoto, Daniela
Queiroz, Maria João R. P.
Abreu, Rui M. V.
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Issue date2012
PublisherWiley-VCH Verlag
Abstract(s)Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in angiogenesis. Herein, we report the synthesis of novel1-aryl-3-[2-, 3- or 4-{thieno[3,2-b ]pyridin-7-ylthio) phenyl]ureas as VEGFR2 inhibitors by promoting the regioselective attack of the thiol group of the 4-aminothiophenol in the chlorine nucleophilic displacement on 7-chlorothieno[3,2-b]pyridine 1, obtaining the aminated compounds Za- c. These were reacted with arylisocyanates to give the corresponding 1,3-diarylureas 3a-c, 4a-c and Sa-c (see scheme).
AccessOpen access
Appears in Collections:CDQuim - Comunicações e Proceedings

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