Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/22298

TitleStudies on the biodistribution of dextrin nanoparticles
Author(s)Gonçalves, C.
Ferreira, M. F. M.
Santos, A. C.
Prata, M. I. M.
Martins, J. A.
Geraldes, C. F. G. C.
Gama, F. M.
Issue date2010
PublisherIOP Publishing
JournalNanotechnology
Abstract(s)The characterization of biodistribution is a central requirement in the development of biomedical applications based on the use of nanoparticles, in particular for controlled drug delivery. The blood circulation time, organ biodistribution and rate of excretion must be well characterized in the process of product development. In this work, the biodistribution of recently developed self-assembled dextrin nanoparticles is addressed. Functionalization of the dextrin nanoparticles with a DOTA-monoamide-type metal chelator, via click chemistry, is described. The metal chelator-functionalized nanoparticles were labeled with the ᵧ-emitting 153Sm3+ radioisotope and the blood clearance rate and organ biodistribution of the nanoparticles were obtained. The effect of PEG surface coating on the blood clearance rate and organ biodistribution of the nanoparticles was also studied.
TypeArticle
URIhttp://hdl.handle.net/1822/22298
DOI10.1088/0957-4484/21/29/295103
ISSN1361-6528
Other identifiers0957-4484
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

Files in This Item:
File Description SizeFormat 
0957-4484_21_29_295103.pdf363,84 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID