Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/22060

TítuloDiels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitors
Autor(es)Salgueiro, D. A. L.
Sousa, Cristina
Fortes, A. Gil
Alves, M. José
Palavras-chaveAzafagomine
Biological activity
Diels-alder cycloaddition
Glycosidase inhibitors
Monocyclic analogs
Azasugars
Data2012
EditoraBentham Science Publishers
RevistaMini Reviews in Medicinal Chemistry
Resumo(s)This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification. There are two asymmetric cycloadditions leading to 1-azafagomine or to an analog. In one case both enantiomers of 1-azafagomine were prepared together with a pair of derivatives. The study comprises glycosidase inhibition studies of the target compounds to a set of glycosidic enzymes, and evidenced molecular features that enhance or diminish their activity as glycosidase inhibitors.
Tipoarticle
URIhttp://hdl.handle.net/1822/22060
DOI10.2174/138955712803832663
ISSN1389-5575
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:CDQuim - Artigos (Papers)

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
MRMC-Manuscript-revised,2012,12,1465-1476.pdfMRMC20121,2 MBAdobe PDFVer/Abrir

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu Currículo DeGóis