Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/22060

TítuloDiels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitors
Autor(es)Salgueiro, D. A. L.
Sousa, Cristina
Fortes, A. Gil
Alves, M. José
Biological activity
Diels-alder cycloaddition
Glycosidase inhibitors
Monocyclic analogs
EditoraBentham Science Publishers
RevistaMini Reviews in Medicinal Chemistry
Resumo(s)This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification. There are two asymmetric cycloadditions leading to 1-azafagomine or to an analog. In one case both enantiomers of 1-azafagomine were prepared together with a pair of derivatives. The study comprises glycosidase inhibition studies of the target compounds to a set of glycosidic enzymes, and evidenced molecular features that enhance or diminish their activity as glycosidase inhibitors.
Arbitragem científicayes
Aparece nas coleções:CDQuim - Artigos (Papers)

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MRMC-Manuscript-revised,2012,12,1465-1476.pdfMRMC20121,2 MBAdobe PDFVer/Abrir

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