Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22060
Título: | Diels-alder cycloaddition in the synthesis of 1-azafagomine, analogs, and derivatives as glycosidase inhibitors |
Autor(es): | Salgueiro, D. A. L. Sousa, Cristina Fortes, A. Gil Alves, M. José |
Palavras-chave: | Azafagomine Biological activity Diels-alder cycloaddition Glycosidase inhibitors Monocyclic analogs Azasugars |
Data: | 2012 |
Editora: | Bentham Science Publishers |
Revista: | Mini Reviews in Medicinal Chemistry |
Resumo(s): | This comprehensive review deals with the synthesis of 1-azafagomine, analogs, and derivatives having the Diels-Alder cycloaddition as the key step. Most of the compounds referred are racemic or have been resolved by lipase transesterification. There are two asymmetric cycloadditions leading to 1-azafagomine or to an analog. In one case both enantiomers of 1-azafagomine were prepared together with a pair of derivatives. The study comprises glycosidase inhibition studies of the target compounds to a set of glycosidic enzymes, and evidenced molecular features that enhance or diminish their activity as glycosidase inhibitors. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22060 |
DOI: | 10.2174/138955712803832663 |
ISSN: | 1389-5575 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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MRMC-Manuscript-revised,2012,12,1465-1476.pdf | MRMC2012 | 1,2 MB | Adobe PDF | Ver/Abrir |