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dc.contributor.authorFerreira, Miguel Filipe Moreira Marques-
dc.contributor.authorMousavi, Bibimaryam-
dc.contributor.authorFerreira, Paula M. T.-
dc.contributor.authorMartins, Catarina-
dc.contributor.authorHelm, Lothar-
dc.contributor.authorMartins, José A.-
dc.contributor.authorGeraldes, Carlos F. G. C.-
dc.identifier.citationDalton Trans., 2012,41, 5472-5475por
dc.description.abstractGold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The relaxivity is limited by chelate flexibility. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.por
dc.description.sponsorshipFundação para a Ciência e Tecnologiapor
dc.description.sponsorshipProjecto PTDC/QUI/70063/2006por
dc.description.sponsorshipPhD grant SFRH/BD/63994/2008 to Miguel Ferreirapor
dc.description.sponsorshipRede Nacional de RMN REDE/1517/RMN/2005 for the acquisition of the Varian VNMRS 600 NMR spectrometer in Coimbra and the Bruker Avance-3 400 Plus in Bragapor
dc.description.sponsorshipB. Mousavi and L. Helm acknowledge financial support by the Swiss National Science Foundation.por
dc.description.sponsorshipCOST D38 Actionpor
dc.publisherRoyal Society of Chemistrypor
dc.subjectGold nanoparticlespor
dc.subjectGd3+ chelatespor
dc.subjectFast water exchangepor
dc.subjectKinetic inertnesspor
dc.subjectSafe for in vivo applicationspor
dc.subjectHigh relaxivitypor
dc.subjectContrast agents for MRIpor
dc.subjectPH stabilitypor
dc.titleGold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRIpor
oaire.citationTitleDalton Transactionspor
sdum.journalDalton Transactionspor
Appears in Collections:CDQuim - Artigos (Papers)

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