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TitleGold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI
Author(s)Ferreira, Miguel Filipe Moreira Marques
Mousavi, Bibimaryam
Ferreira, Paula M. T.
Martins, Catarina
Helm, Lothar
Martins, José A.
Geraldes, Carlos F. G. C.
KeywordsGold nanoparticles
Gd3+ chelates
Fast water exchange
Kinetic inertness
Safe for in vivo applications
High relaxivity
Contrast agents for MRI
PH stability
Issue date2012
PublisherRoyal Society of Chemistry
JournalDalton Transactions
CitationDalton Trans., 2012,41, 5472-5475
Abstract(s)Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The relaxivity is limited by chelate flexibility. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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