Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

Utilize este identificador para referenciar este registo: https://hdl.handle.net/1822/22024

Título:	Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI
Autor(es):	Ferreira, Miguel Filipe Moreira Marques Mousavi, Bibimaryam Ferreira, Paula M. T. Martins, Catarina Helm, Lothar Martins, José A. Geraldes, Carlos F. G. C.
Palavras-chave:	Gold nanoparticles Gd3+ chelates Fast water exchange Kinetic inertness Safe for in vivo applications High relaxivity Contrast agents for MRI PH stability
Data:	2012
Editora:	Royal Society of Chemistry
Revista:	Dalton Transactions
Citação:	Dalton Trans., 2012,41, 5472-5475
Resumo(s):	Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The relaxivity is limited by chelate flexibility. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.
Tipo:	Artigo
URI:	https://hdl.handle.net/1822/22024
DOI:	10.1039/c2dt30388d
ISSN:	0300-9246
Arbitragem científica:	yes
Acesso:	Acesso aberto
Aparece nas coleções:	CDQuim - Artigos (Papers)