Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/21987

TitleRole of the ubiquitin–proteasome system in nervous system function and disease : using C. elegans as a dissecting tool
Author(s)Baptista, Márcio S.
Duarte, Carlos B.
Maciel, P.
KeywordsUbiquitylation
E1, E2, E3
De-ubiquitylase
Nematode
Neurodevelopment
Neurodegeneration
Synaptic plasticity
Neurological disease
E1
E2
E3
Issue dateAug-2012
PublisherSpringer
JournalCellular and Molecular Life Sciences
Abstract(s)In addition to its central roles in protein quality control, regulation of cell cycle, intracellular signaling, DNA damage response and transcription regulation, the ubiquitin– proteasome system (UPS) plays specific roles in the nervous system, where it contributes to precise connectivity through development, and later assures functionality by regulating a wide spectrum of neuron-specific cellular processes. Aberrations in this system have been implicated in the etiology of neurodevelopmental and neurodegenerative diseases. In this review, we provide an updated view on the UPS and highlight recent findings concerning its role in normal and diseased nervous systems. We discuss the advantages of the model organism Caenorhabditis elegans as a tool to unravel the major unsolved questions concerning this biochemical pathway and its involvement in nervous system function and dysfunction, and expose the new possibilities, using state-ofthe- art techniques, to assess UPS function using this model system.
TypeArticle
URIhttp://hdl.handle.net/1822/21987
DOI10.1007/s00018-012-0946-0
ISSN1420-682X
Publisher versionhttp://link.springer.com/
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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