Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/21983

TitleDownregulation of RKIP is associated with poor outcome and malignant progression in gliomas
Author(s)Martinho, Olga
Granja, Sara Costa
Jaraquemada, Teresa
Caeiro, Cláudia
Gonçalves, Vera M.
Honavar, Mrinalini
Costa, Paulo
Damasceno, Margarida
Rosner, Marsha R.
Lopes, José M.
Reis, R. M.
Issue dateJan-2012
PublisherPublic Library of Science
JournalPloS One
Abstract(s)Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis and prognosis in several human neoplasms. Its role in the prognosis and tumourigenesis of gliomas remains unclear. In the present study, we found that RKIP protein is absent in a low frequency (10%, 20/193) of glioma tumors. Nevertheless, the absence of RKIP expression was an independent prognostic marker in glioma. Additionally, by in vitro downregulation of RKIP, we found that RKIP inhibition induces a higher viability and migration of the cells, having no effect on cellular proliferation and angiogenesis, as assessed by in vivo CAM assay. In conclusion, this is the largest series studied so far evaluating the expression levels of this important cancer suppressor protein in glioma tumors. Our results suggest that in a subset of tumors, the absence of RKIP associates with highly malignant behavior and poor survival of patients, which may be a useful biomarker for tailored treatment of glioma patients.
TypeArticle
URIhttp://hdl.handle.net/1822/21983
DOI10.1371/journal.pone.0030769
ISSN1932-6203
Publisher versionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0030769
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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