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dc.contributor.authorFirmino, A. D. G.-
dc.contributor.authorRaju, B. Rama-
dc.contributor.authorGonçalves, M. Sameiro T.-
dc.description.abstractMicrowave irradiation was used for the first time in an efficient synthesis of benzo[a]phenoxazinium chlorides. The main advantage of this protocol is the notable reduction in reaction times and good to excellent yields of the products were achieved in comparison with classical heating conditions as described. These new series of compounds possess 5-amine and/or 2-hydroxyl substituents in the polycyclic system to improve their solubility in aqueous media, in addition to the functional groups as terminals in the side chains, allowing their further use in covalent labeling. Fundamental photophysical studies carried out in ethanol, physiological pH and water revealed that all cationic fluorophores absorbed and emitted in the range of 610-628 nm and 630-652 nm, respectively, with relative fluorescent quantum yields ranging from 0.16 to 0.96.por
dc.description.sponsorshipFundação para a Ciência e Tecnologia (Portugal) - financial support to the Research Centres, CQ/UM [PEst-C/QUI/UI0686/2011 (FCOMP-01-0124-FEDER-022716)] and CFUM [PEst-C/FIS/UI0607/2011 (F-COMP-01-0124-FEDER-022711)], FEDER-COMPETE, FCT-Portugal. FCT, POPH-QREN, FSE - a post-doctoral grant (SFRH/BPD/62881/2009) to B. R. Raju The NMR spectrometer Bruker Avance III 400 is part of the National NMR Network and was purchased in the framework of the National Program for Scientific Re-equipment, contract REDE/1517/RMN/2005 with funds from POCI 2010 (FEDER) and FCT.por
dc.publisherWiley-VCH Verlagpor
dc.subjectNile blue derivativespor
dc.subjectFunctionalised labelspor
dc.subjectMicrowave irradiationpor
dc.subjectFluorescent probespor
dc.titleMicrowave synthesis of novel water-soluble 2-, 5- and 9-substituted benzo[a]phenoxazinium chlorides in comparison with conventional heatingpor
oaire.citationTitleEuropean Journal of Organic Chemistrypor
sdum.journalEuropean Journal of Organic Chemistrypor
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