Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/21368

TitleAnimal welfare in studies on murine tuberculosis : assessing progress over a 12-year period and the need for further improvement
Author(s)Franco, Nuno
Neves, Margarida Correia
Olsson, Anna
KeywordsAnimal welfare
Tuberculosis
Mouse
Models of infection
Issue dateOct-2012
PublisherPublic Library of Science
JournalPLoS ONE
Abstract(s)There is growing concern over the welfare of animals used in research, in particular when these animals develop pathology. The present study aims to identify the main sources of animal distress and to assess the possible implementation of refinement measures in experimental infection research, using mouse models of tuberculosis (TB) as a case study. This choice is based on the historical relevance of mouse studies in understanding the disease and the present and long-standing impact of TB on a global scale. Literature published between 1997 and 2009 was analysed, focusing on the welfare impact on the animals used and the implementation of refinement measures to reduce this impact. In this 12-year period, we observed a rise in reports of ethical approval of experiments. The proportion of studies classified into the most severe category did however not change significantly over the studied period. Information on important research parameters, such as method for euthanasia or sex of the animals, were absent in a substantial number of papers. Overall, this study shows that progress has been made in the application of humane endpoints in TB research, but that a considerable potential for improvement remains.
TypeArticle
URIhttp://hdl.handle.net/1822/21368
DOI10.1371/journal.pone.0047723
ISSN1932-6203
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Franco N_PlosOne 2012.pdfDocumento principal723,51 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID