Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/21367

TitleRole of monocarboxylate transporters in human cancers : state of the art
Author(s)Pinheiro, Céline
Longatto Filho, Adhemar
Azevedo, João Silva
Casal, Margarida
Schmitt, Fernando C.
Baltazar, Fátima
KeywordsMonocarboxylate transporters
Cancer
Warburg effect
Lactate
Issue dateMar-2012
PublisherSpringer
JournalJournal of Bioenergetics and Biomembranes
Abstract(s)Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the transmembrane transport of pyruvate, lactate and ketone bodies. The role of MCTs in cell homeostasis has been characterized in detail in normal tissues, however, their role in cancer is still far from understood. Most solid tumors are known to rely on glycolysis for energy production and this activity leads to production of important amounts of lactate, which are exported into the extracellular milieu, contributing to the acidic microenvironment. In this context, MCTs will play a dual role in the maintenance of the hyper-glycolytic acidresistant phenotype of cancer, allowing the maintenance of the high glycolytic rates by performing lactate efflux, and pH regulation by the co-transport of protons. Thus, they constitute attractive targets for cancer therapy, which have been little explored. Here we review the literature on the role of MCTs in solid tumors in different locations, such as colon, central nervous system, breast, lung, gynecologic tract, prostate, stomach, however, there are many conflicting results and in most cases there are no functional studies showing the dependence of the tumors on MCT expression and activity. Additional studies on MCT expression in other tumor types, confirmation of the results already published as well as additional functional studies are needed to deeply understand the role of MCTs in cancer maintenance and aggressiveness.
TypeArticle
URIhttp://hdl.handle.net/1822/21367
DOI10.1007/s10863-012-9428-1
ISSN0145-479X
Publisher versionhttp://link.springer.com/article/10.1007%2Fs10863-012-9428-1
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Pinheiro C_J Bioenerg Biomembr 2012 pp.pdfAuthor's proof673,64 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID