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TitleModulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus
Author(s)Mesquita, Sandro
Ferreira, A. C.
Sousa, João Carlos
Santos, Nadine Correia
Neves, Margarida Correia
Sousa, Nuno
Palha, Joana Almeida
Marques, Fernanda
Cerebrospinal fluid
Alzheimer’s disease
Issue date22-May-2012
PublisherFrontiers Media
JournalFrontiers in Cellular Neuroscience
Abstract(s)Iron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach the brain through receptor-mediated endocytosis of iron-bound transferrin by the brain barriers, the blood-cerebrospinal fluid (CSF) barrier, formed by the choroid plexus (CP) epithelial cells and the blood-brain barrier (BBB) formed by the endothelial cells of the brain capillaries. Importantly, the CP epithelial cells are responsible for producing most of the CSF, the fluid that fills the brain ventricles and the subarachnoid space. Recently, the finding that the CP epithelial cells display all the machinery to locally control iron delivery into the CSF may suggest that the general and progressive senescence of the CP may be at the basis of the impairment of regional iron metabolism, iron-mediated toxicity, and the increase in inflammation and oxidative stress that occurs with aging and, particularly, in AD.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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