Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/2057

TitleSynthesis and intramolecular cyclization of novel beta,beta-bis(benzo[b]thienyl)dehydroalanine derivatives
Author(s)Abreu, Ana S.
Silva, Natália O.
Ferreira, Paula M. T.
Queiroz, Maria João R. P.
KeywordsBeta,beta-dibromodehydroalanine
Beta,beta-bis-(benzo[b]thienyldehydroalanine
Suzuki cross coupling
Pyrrole derivatives
β,β-bis-(benzo[b]thienyl) dehydroalanine
β,β-dibromodehydroalanine
Issue date2003
PublisherElsevier
JournalTetrahedron Letters
Citation"Tetrahedron letters". 44 (2003) 3377-3379.
Abstract(s)The methyl ester of tert-butyloxycarbonyl-beta,beta-dibromodehydroalanine was obtained in a one pot procedure from bis-(N-tert-butyloxycarbonyl)dehydroalanine. The former was reacted with several boronic benzo[b]thiophene acids under Suzuki cross coupling conditions, to give new beta,beta-bis-(benzo[b]thienyl)dehydroalanines in high yields. These compounds were cyclized to pyrrole derivatives by treatment with Pd(OAc)2 and Cu(OAc)2 in DMF.
TypeArticle
URIhttp://hdl.handle.net/1822/2057
DOI10.1016/S0040-4039(03)00564-1
ISSN0040-4039
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

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