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|Title:||Synthesis and intramolecular cyclization of novel beta,beta-bis(benzo[b]thienyl)dehydroalanine derivatives|
|Author(s):||Abreu, Ana S.|
Silva, Natália O.
Ferreira, Paula M. T.
Queiroz, Maria João R. P.
Suzuki cross coupling
|Citation:||"Tetrahedron letters". 44 (2003) 3377-3379.|
|Abstract(s):||The methyl ester of tert-butyloxycarbonyl-beta,beta-dibromodehydroalanine was obtained in a one pot procedure from bis-(N-tert-butyloxycarbonyl)dehydroalanine. The former was reacted with several boronic benzo[b]thiophene acids under Suzuki cross coupling conditions, to give new beta,beta-bis-(benzo[b]thienyl)dehydroalanines in high yields. These compounds were cyclized to pyrrole derivatives by treatment with Pd(OAc)2 and Cu(OAc)2 in DMF.|
|Appears in Collections:||CDQuim - Artigos (Papers)|