Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/19387

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dc.contributor.authorAlves, A.-
dc.contributor.authorPinho, Elisabete D.-
dc.contributor.authorNeves, N. M.-
dc.contributor.authorSousa, R. A.-
dc.contributor.authorReis, R. L.-
dc.date.accessioned2012-05-18T11:08:23Z-
dc.date.available2012-05-18T11:08:23Z-
dc.date.issued2012-04-
dc.identifier.issn0378-5173por
dc.identifier.urihttp://hdl.handle.net/1822/19387-
dc.description.abstractThe polysaccharide ulvan, composed of sulphated rhamnose, glucoronic and iduronic acids was used to produce polymeric membranes by solvent casting. As ulvan is soluble in water, a cross-linking step was necessary to render the membrane insoluble in water and stable at physiological conditions. Crosslinked ulvan membranes were characterized by FTIR, SEM, swelling behaviour was investigated and the mechanical performance assessed by quasi-static tensile testing. Furthermore, the ability and mechanism of sustained release of a model drug from ulvan membranes was investigated. Produced membranes revealed remarkable ability to uptake water (up to ∼1800% of its initial dry weight) and increased mechanical performance (1.76 MPa) related with cross-linking. On the other hand, medicated ulvan dressings demonstrate the potential as drug delivery devices. Using a model drug we have observed an initial steady release of the drug – of nearly 49% – followed by slower and sustained release up to 14 days. The properties of ulvan membranes herein revealed suggest a great potential of this natural sulphated polysaccharide as a wound dressing.por
dc.description.sponsorshipAnabela Alves is grateful for financial support from Fundacao para a Ciencia e Tecnologia through the SFRH/BD/39359/2007 grant. This work was partially supported by the project IBERO-MARE approved by Operational Programme for Cross-border Cooperation: Spain-Portugal, 2007-2013 (POCTEP), with funding contribution through the European Regional Development Fund (ERDF co-funding) and POCTEP. A. Alves also acknowledges V tor Correlo for his support and help.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsrestrictedAccesspor
dc.subjectUlvanpor
dc.subjectMembranepor
dc.subjectDressingpor
dc.subjectMedicated dressingpor
dc.subjectDrug deliverypor
dc.titleProcessing ulvan into 2D structures : cross-linked ulvan membranes as new biomaterials for drug delivery applicationspor
dc.typearticle-
dc.peerreviewedyespor
sdum.publicationstatuspublishedpor
oaire.citationStartPage76por
oaire.citationEndPage81por
oaire.citationIssue1-2por
oaire.citationTitleInternational Journal of Pharmaceuticspor
oaire.citationVolume426por
dc.identifier.doi10.1016/j.ijpharm.2012.01.021por
dc.identifier.pmid22281048por
dc.subject.wosScience & Technologypor
sdum.journalInternational Journal of Pharmaceuticspor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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