Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/18664

TitleImmunity and tolerance to infections in experimental hematopoietic transplantation
Author(s)Carvalho, Agostinho
Cunha, Cristina
Romani, Luigina
KeywordsStem cell transplantation
Fungal infections
Immunity
Inflammation
Immunotherapy
Single nucleotide polymorphism
Genetic susceptibility
Dendritic cells
Epithelial cells
Issue dateSep-2011
PublisherElsevier
JournalBest Practice & Research. Clinical Haematology
Abstract(s)Resistance and tolerance are two types of host defense mechanisms that increase fitness in response to fungi. Several genetic polymorphisms in pattern recognition receptors, most remarkably Toll-like receptors (TLRs), have been described to influence resistance and tolerance to aspergillosis in distinct clinical settings. TLRs on dendritic cells pivotally contribute in determining the balance between immunopathology and protective immunity to the fungus. Epithelial cells also contribute to this balance via selected TLRs converging on indoleamine-2,3-dioxygenase (IDO). Studies in experimental hematopoietic transplantation confirmed the dichotomy of pathways leading to resistance and tolerance to the fungus providing new insights on the relative contribution of the hematopoietic/nonhematopoietic compartments.
TypeArticle
URIhttp://hdl.handle.net/1822/18664
DOI10.1016/j.beha.2011.04.006
ISSN1521-6926
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S1521692611000429
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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