Please use this identifier to cite or link to this item:

TitleImmunity and tolerance to infections in experimental hematopoietic transplantation
Author(s)Carvalho, Agostinho
Cunha, Cristina
Romani, Luigina
KeywordsStem cell transplantation
Fungal infections
Single nucleotide polymorphism
Genetic susceptibility
Dendritic cells
Epithelial cells
Issue dateSep-2011
JournalBest Practice & Research. Clinical Haematology
Abstract(s)Resistance and tolerance are two types of host defense mechanisms that increase fitness in response to fungi. Several genetic polymorphisms in pattern recognition receptors, most remarkably Toll-like receptors (TLRs), have been described to influence resistance and tolerance to aspergillosis in distinct clinical settings. TLRs on dendritic cells pivotally contribute in determining the balance between immunopathology and protective immunity to the fungus. Epithelial cells also contribute to this balance via selected TLRs converging on indoleamine-2,3-dioxygenase (IDO). Studies in experimental hematopoietic transplantation confirmed the dichotomy of pathways leading to resistance and tolerance to the fungus providing new insights on the relative contribution of the hematopoietic/nonhematopoietic compartments.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Carvalho A_Best Pract Res Clin Haematol-prep 2011.pdfVersão preprint587,06 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID