Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/18637

TitleLymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours
Author(s)Oliveira, Antônio Talvane Torres
Reis, R. M.
Afonso, Julieta Alexandra Pereira
Martinho, Olga
Matos, Delcio
Carvalho, André Lopes
Vazquez, Vinícius Lima
Silva, Thiago Buosi
Scapulatempo-Neto, Cristovam
Saad, Sarhan Sydney
Longatto Filho, Adhemar
KeywordsGastrointestinal stromal tumours
KIT
D2-40
VEGF-C
VEGFR-3
Issue dateNov-2011
PublisherUniversidad de Murcia
JournalHistology and Histopathology
Abstract(s)This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density – BDV – assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST’s cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD.
TypeArticle
URIhttp://hdl.handle.net/1822/18637
ISSN0213-3911
Publisher versionhttp://www.hh.um.es/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
de Oliveira AT_ Histol Histopathol 2011.pdfDocumento principal1,51 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID