Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/18618
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Carvalho, Agostinho | - |
dc.contributor.author | Osório, Nuno S. | - |
dc.contributor.author | Saraiva, Margarida | - |
dc.contributor.author | Cunha, Cristina | - |
dc.contributor.author | Almeida, A. J. | - |
dc.contributor.author | Coelho, Maria Teixeira | - |
dc.contributor.author | Ludovico, Paula | - |
dc.contributor.author | Pedrosa, Jorge | - |
dc.contributor.author | Pitzurra, Lucia | - |
dc.contributor.author | Aversa, Franco | - |
dc.contributor.author | Romani, Luigina | - |
dc.contributor.author | Castro, António G. | - |
dc.contributor.author | Rodrigues, Fernando José dos Santos | - |
dc.date.accessioned | 2012-04-13T14:43:21Z | - |
dc.date.available | 2012-04-13T14:43:21Z | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 1932-6203 | por |
dc.identifier.uri | https://hdl.handle.net/1822/18618 | - |
dc.description.abstract | In humans, allelic variants in Toll-like receptors (TLRs) associate with several pathologies. However, the underlying cellular and molecular mechanisms of this association remain largely unknown. Analysis of the human TLR9 promoter revealed that the C allele of the rs5743836 polymorphism generates several regulatory sites, including an IL-6-responding element. Here, we show that, in mononuclear cells carrying the TC genotype of rs5743836, IL-6 up-regulates TLR9 expression, leading to exacerbated cellular responses to CpG, including IL-6 production and B-cell proliferation. Our study uncovers a role for the rs5743836 polymorphism in B-cell biology with implications on TLR9-mediated diseases and on the therapeutic usage of TLR9 agonists/antagonists. | por |
dc.description.sponsorship | Fundação para a Ciência e Tecnologia (FCT) This study was supported by FCT - Grant Number PIC/IC/83313/2007. | por |
dc.language.iso | eng | por |
dc.publisher | Public Library of Science | por |
dc.rights | openAccess | por |
dc.subject | Allelic variants | por |
dc.subject | Toll-like receptors (TLRs) | por |
dc.subject | Human TLR9 promoter | por |
dc.subject | rs5743836 polymorphism | por |
dc.subject | IL-6-responding element | por |
dc.subject | B-cell proliferation | por |
dc.subject | TLR9 agonists | por |
dc.subject | TLR9 antagonists | por |
dc.title | The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://dx.doi.org/10.1371/journal.pone.0028256 | por |
oaire.citationStartPage | e28256 | por |
oaire.citationIssue | 11 | por |
oaire.citationTitle | PLoS One | por |
oaire.citationVolume | 6 | por |
dc.identifier.doi | 10.1371/journal.pone.0028256 | por |
dc.identifier.pmid | 22132241 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | PLoS ONE | por |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Carvalho A_PLoS One 2011.pdf | Documento principal | 378,08 kB | Adobe PDF | Ver/Abrir |