Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/18615

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dc.contributor.authorCarvalho, Miguel-
dc.contributor.authorTeixeira, Fábio Gabriel Rodrigues-
dc.contributor.authorReis, Rui L.-
dc.contributor.authorSousa, Nuno-
dc.contributor.authorSalgado, A. J.-
dc.date.accessioned2012-04-13T11:37:55Z-
dc.date.available2012-04-13T11:37:55Z-
dc.date.issued2011-09-
dc.identifier.issn1574-888Xpor
dc.identifier.urihttp://hdl.handle.net/1822/18615-
dc.description.abstractMesenchymal Stem Cells (MSCs), have been defined and characterized by: 1) their ability to adhere to plastic culture flasks; 2) the positive expression of CD105, CD73, CD90 membrane antigens, and the lack of expression of others (e.g CD45 and CD34) and 3) the ability of differentiation under adequate conditions along the osteogenic, chondrogenic and adipogenic lineages. In recent years, cells with these characteristics have been isolated from the Wharton’s jelly of the Umbilical Cord (UC). Similarly to bone marrow MSCs, they have shown multilineage differentiation potential and to be able to provide trophic support to neighboring cells. According to the literature, there are two main populations of cells with a mesenchymal character within the human UC: Wharton's jelly Mesenchymal Stem Cells (WJ-MSCs) and Human Umbilical Cord Perivascular Cells (HUCPVCs). In the present work our aim is to make a comprehensive review on MSC populations of the UC and how these cell populations may be used for future applications in CNS regenerative medicine. Following a brief insight on the general characteristics of MSC like cells, we will discuss the possible sources of stem cells within the WJ and the cord itself (apart UC blood), as well as their phenotypic character. As it has already been shown that these cells hold a strong trophic support to neighbouring cell populations, we will then focus on their secretome, namely which molecules have already been identified within it and their role in phenomena such as immunomodulation. The possible applications of these cell populations to CNS regenerative medicine will be addressed by critically reviewing the work that has been performed so far in this field. Finally, a brief insight will be made on what in the authors’ opinion are the major challenges in the field for the future application of these cell populations in CNS regenerative medicine.por
dc.description.sponsorshipfunds attributed by Fundação Calouste de Gulbenkian to A.J. Salgado under the scope of the The Gulbenkian Programme to Support research in Life Sciences; Portuguese Foundation for Science and Technology (FCT) (PhD scholarship to M.M. Carvalho - SFRH / BD / 51061 / 2010).por
dc.language.isoengpor
dc.publisherBentham Science Publisherspor
dc.rightsopenAccesspor
dc.subjectMesenchymal stem cellspor
dc.subjectumbilical cordpor
dc.subjectWharton’s jellypor
dc.subjectSecretomepor
dc.titleMesenchymal stem cells in the umbilical cord : phenotypic characterization, secretome and applications in central nervous system regenerative medicinepor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.benthamdirect.org/pages/content.php?CSCR/2011/00000006/00000003/0005CSCR.SGMpor
oaire.citationStartPage221por
oaire.citationEndPage228por
oaire.citationIssue3por
oaire.citationTitleCurrent Stem Cell Research and Therapypor
oaire.citationVolume6por
dc.identifier.doi10.2174/157488811796575332por
dc.identifier.pmid21476975por
dc.subject.wosScience & Technologypor
sdum.journalCurrent Stem Cell Research and Therapypor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals
ICVS - Artigos em Revistas Internacionais com Referee

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