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TitleSupercritical polymerization and impregnation of molecularly imprinted polymers for drug delivery
Author(s)Duarte, Ana Rita C.
Casimiro, T.
Duarte, A. A.
Simplicio, A. L.
Duarte, Catarina M. M.
Issue date2006
JournalThe Journal of Supercritical Fluids
Abstract(s)Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems.
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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