Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/17364

TitleGLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression
Author(s)Pinheiro, Céline
Sousa, Bárbara
Albergaria, André
Paredes, Joana
Dufloth, Rozany
Vieira, Daniella
Schmitt, Fernando C.
Baltazar, Fátima
KeywordsGLUT1
CAIX
Monocarboxylate transporters (MCTs)
CD147/EMMPRIN
Breast carcinoma
Immunohistochemistry
Issue dateOct-2011
PublisherConsejería de Sanidad de la Comunidad Autónoma de Murcia
Sociedad Española de Histología e Ingeniería Tisular; Histology and Histopathology
JournalHistology and Histopathology
Abstract(s)The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in breast cancer. The clinico-pathological value of GLUT1 and CAIX was also evaluated. For that, we analysed the immunohistochemical expression of GLUT1 and CAIX, in a large series of invasive breast carcinoma samples (n=124), previously characterized for MCT1, MCT4 and CD147 expression. GLUT1 expression was found in 46% of the cases (57/124), while CAIX was found in 18% of the cases (22/122). Importantly, both MCT1 and CD147, but not MCT4, were associated with GLUT1 and CAIX expression. Also, GLUT1 and CAIX correlated with each other. Concerning the clinico-pathological values, GLUT1 was associated with high grade tumours, basal-like subtype, absence of progesterone receptor, presence of vimentin and high proliferative index as measured by Ki-67. Additionally, CAIX was associated with large tumour size, high histological grade, basal-like subtype, absence of estrogen and progesterone receptors and presence of basal cytokeratins and vimentin expression. Finally, patients with CAIX positive tumours had a significantly shorter disease-free survival. The association between MCT1 and both GLUT1 and CAIX may result from hypoxia-mediated metabolic adaptations, which confer a glycolytic, acid-resistant and more aggressive phenotype to cancer cells.
TypeArticle
DescriptionWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study.
URIhttp://hdl.handle.net/1822/17364
ISSN0213-3911
Publisher versionhttp://www.hh.um.es/2011/HH_26_10_2011.htm
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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