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TitleAn AIF orthologue regulates apoptosis in yeast
Author(s)Wissing, Silke
Ludovico, Paula
Herker, Eva
Buttner, Sabrina
Engelhardt, Silvia
Decker, Thorsten
Link, Alexander
Proksch, Astrid
Rodrigues, Fernando José dos Santos
Côrte-Real, Manuela
Frohlich, Kai-Uwe
Manns, Joachim
Candé, Céline
Sigrist, Stephen J.
Kroemer, Guido
Madeo, Frank
apoptosis-inducing factor
cyclophilin A
Issue date2004
PublisherRockefeller University Press
JournalJournal of Cell Biology
Citation"The journal of cell biology". ISSN 0021-9525. 166:7 (2004) 969-974.
Abstract(s)Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode of action are controversial. Here, we show that the yeast AIF homologue Ynr074cp controls yeast apoptosis. Similar to mammalian AIF, Ynr074cp is located in mitochondria and translocates to the nucleus of yeast cells in response to apoptotic stimuli. Purified Ynr074cp degrades yeast nuclei and plasmid DNA. YNR074C disruption rescues yeast cells from oxygen stress and delays age-induced apoptosis. Conversely, overexpression of Ynr074cp strongly stimulates apoptotic cell death induced by hydrogen peroxide and this effect is attenuated by disruption of cyclophilin A or the yeast caspase YCA1. We conclude that Ynr074cp is a cell death effector in yeast and rename it AIF-1 (Aif1p, gene AIF1).
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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