Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/16782

TitleSynthesis and characterization of self-assembled nanogels made of pullulan
Author(s)Ferreira, Sílvia A.
Coutinho, Paulo J. G.
Gama, F. M.
KeywordsPullulan
Synthetic nanogels
Self-assembly
Amphiphilic macromolecular micelles
Michael addition
Hydrophobic domains
Issue dateMar-2011
PublisherMDPI Publishing
JournalMaterials
Abstract(s)Self-assembled nanogels made of hydrophobized pullulan were obtained using a versatile, simple, reproducible and low-cost method. In a first reaction pullulan was modified with hydroxyethyl methacrylate or vinyl methacrylate, further modified in the second step with hydrophobic 1-hexadecanethiol, resulting as an amphiphilic material, which self-assembles in water via the hydrophobic interaction among alkyl chains. Structural features, size, shape, surface charge and stability of the nanogels were studied using hydrogen nuclear magnetic resonance, fluorescence spectroscopy, cryo-field emission scanning electron microscopy and dynamic light scattering. Above the critical aggregation concentration spherical polydisperse macromolecular micelles revealed long-term colloidal stability in aqueous medium, with a nearly neutral negative surface charge and mean hydrodynamic diameter in the range 100-400 nm, depending on the polymer degree of substitution. Good size stability was observed when nanogels were exposed to potential destabilizing conditions of pH. While the size stability of the nanogel made of pullulan with vinyl methacrylate and more hydrophobic chains grafted was affected by the ionic strength and urea, nanogel made of pullulan with hydroxyethyl methacrylate and fewer hydrophobic chains grafted remained stable.
TypeArticle
URIhttp://hdl.handle.net/1822/16782
DOI10.3390/ma4040601
ISSN1996-1944
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FAMO - Artigos/Papers (with refereeing)

Files in This Item:
File Description SizeFormat 
3610.pdf946,88 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID