Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/16683

TitlePotential programming of dopaminergic circuits by early life stress
Author(s)Rodrigues, Ana João
Leão, Pedro
Carvalho, M.
Almeida, O. F. X.
Sousa, Nuno
KeywordsProgramming
Glucocorticoids
Dopamine
Mesolimbic
Mesocortical
Nigrostriatal
Tuberoinfundibular
Addiction
Depression
Anxiety
Nucleus accumbens
Ventral tegmental area
Issue date2011
PublisherSpringer
JournalPsychopharmacology
Abstract(s)Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.
TypeArticle
URIhttp://hdl.handle.net/1822/16683
DOI10.1007/s00213-010-2085-3
ISSN0033-3158
Publisher versionhttp://www.springerlink.com/link-out/?id=3032&code=T76746772852T726
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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