Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/16406

TitleSelf-assembled dextrin nanogel as curcumin delivery system
Author(s)Gonçalves, Catarina
Schellenberg, Peter Michael
Gama, F. M.
Coutinho, Paulo J. G.
Pereira, Paula
KeywordsCurcumin
Dextrin
Nanogel
Drug delivery
Cytotoxicity
Issue date2012
PublisherScientific Research Publishing
JournalJournal of Biomaterials and Nanobiotechnology
Abstract(s)Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effec-tive curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nano-gel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.
TypeArticle
URIhttp://hdl.handle.net/1822/16406
ISSN2158-7027
2158-7043
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FAMO - Artigos/Papers (with refereeing)

Files in This Item:
File Description SizeFormat 
JBNB2012_Nanogel.pdf411,37 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID