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TitleStudies on the hemocompatibility of bacterial cellulose
Author(s)Andrade, Fábia K.
Silva, João P.
Carvalho, Manuela
Castanheira, Elisabete M. S.
Soares, Raquel
Gama, F. M.
KeywordsBacterial cellulose
Cellulose-binding module
Blood compatibility
Vascular grafts
Issue dateSep-2011
JournalJournal of Biomedical Materials Research Part A
Abstract(s)Among the strategies to improve a material’s hemocompatibility, pre-coating with the tripeptide Arg-Gly-Asp (RGD) is used to favor endothelialization thus lowering thrombogenicity. The blood compatibility of native and RGD-modified bacterial cellulose (BC) was studied in this work for the first time. The plasma recalcification time and whole blood clotting results demonstrate the hemocompatibility of BC. A significant amount of plasma protein adsorb to BC fibres, however, according to analysis by intrinsic tryptophan fluorescence techniques when albumin, c-globulin, and fibrinogen from pure protein solutions adsorb to BC do not undergo detectable conformational modifications. Human microvascular endothelial cells cultured on RGD-modified BC readily form a confluent cell layer, inhibiting the adhesion of platelets. As a general conclusion, both native and RGD-modified BCs may be classified as hemocompatible materials.
Publisher version
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series
CDF - FAMO - Artigos/Papers (with refereeing)

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