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TitleMonocarboxylate transporters: new molecular targets for colorectal carcinoma
Author(s)Amorim, Ricardo
Martins, Sandra
Pereira, Helena Paula Fernandes
Pinheiro, Céline
Reis, R. L.
Longatto Filho, Adhemar
Preto, Ana
Baltazar, Fátima
Issue date2011
Abstract(s)[Excerpt] Colorectal carcinoma (CRC) is the second leading cause of cancer-related death in industrialized countries1. 5-Fluorouracil (5-FU) is one of the most efficient chemotherapeutic agents in the treatment of CRC although resistance to 5-FU treatment has been reported2. CRC relies mostly on glycolysis to meet their energetic demands and, as a consequence, CRC cells produce large amounts of lactate that must be extruded to the tumour microenvironment by lactate transporters, namely monocarboxylate transporters (MCTs). (...)
AccessRestricted access (UMinho)
Appears in Collections:DBio - Comunicações/Communications in Congresses

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