Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/15443

TitleVersatile synthesis of 5-aminoimidazole-4-carboxylic acid derivatives
Author(s)Dias, Alice
Vila-Chã, Sofia
Costa, Luísa
Cunha, Daniela
Senhorães, Nádia
Proença, M. Fernanda R. P.
KeywordsHeterocycles
Imidazole
Carboxamidine
Carboximidate
Imidoyl cyanides
Issue date19-Oct-2011
PublisherThieme Medical Publishers
JournalSynlett
Abstract(s)5-Amino imidazole 4-substituted carboxamidines and 4-substituted imidoyl cyanides were selectively obtained under mild experimental conditions from reaction of the easily accessible 5-amino-4-cyanoformimidoyl imidazoles with primary aliphatic and aromatic amines, ammonia and amino acids in a one-pot reaction. When alcohols were used, the corresponding 5-aminoimidazole 4-carboximidates were isolated. An equally simple reaction occurred when starting imidazoles were combined with water to give 5-aminoimidazole 4-acyl cyanides.
TypeArticle
URIhttp://hdl.handle.net/1822/15443
DOI10.1055/s-0031-1289528
ISSN0936-5214
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Artigos (Papers)

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