Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/15410

TitleA facile one-pot synthesis of 3-imidazolyl 1,2,4-triazoles and 1,2,4-oxadiazolones
Author(s)Dias, Alice
Cabral, Isabel
Vila-Chã, Sofia
Cunha, Daniela
Senhorães, Nádia
Nobre, Sandra
Sousa, Cristina
Proença, M. Fernanda R. P.
KeywordsHeterocycles
Cyclization
Ring closure
Imidazole
1,2,4-triazole
1,2,4-oxadiazole
Issue date2010
PublisherThieme Publishing
JournalSynlett
Abstract(s)5-(5-Amino imidazole-4-yl)-1,2,4-triazol-3-ones were obtained under mild experimental conditions from 5-amino-4-(N-ethoxycarbonyl) cyanoformimidoyl imidazoles and hydrazine in a rapid one-pot reaction. When hydroxylamine hydrochloride was used, in the presence of base, the corresponding 1,2,4-oxadiazol-5-ones were isolated. An equally fast reaction occurred when 5-amino-4-(N-acetyl/benzoyl) cyanoformimidoyl imidazoles were combined with hydrazine to give 5-(5-amino imidazole-4-yl)-1,2,4-triazoles.
TypeArticle
URIhttp://hdl.handle.net/1822/15410
DOI10.1055/s-0030-1258820
ISSN0936-5214
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:CDQuim - Artigos (Papers)

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