Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/15303

TitleSonoproduction of liposomes and protein particles as templates for delivery purposes
Author(s)Silva, Raquel
Ferreira, Helena
Paulo, Artur Cavaco
Issue date2011
PublisherACS Publications
JournalBiomacromolecules
Abstract(s)The development of nano and micro delivery systems (DS), so small in size, is growing in importance, such as in drug targeting. In an era where nano is the new trend, micro and nano materials are in the forefront of progress. These systems can be produced by a diversity of methods. However, the use of high-intensity ultrasound offers an easy and versatile tool for nano- and microstructured materials that are often unavailable by conventional methods. Similarly to the synthesis methods that can be used, several starting materials can be applied to produce particulate systems. In this review, the recent strategic development of DS is discussed with emphasis on liposomes and polymer-based, specially protein-based, nanomedicine platforms for drug delivery. Among the variety of applications that materials in the particulate form can have, the control release of drugs is probably the most prominent one, as these have been in the forefront line of interest for biomedical applications. The basic concepts of sonochemical process pertaining to DS are summarized as well as the role of sonochemical procedure to their preparation. The different applications of these systems wrap up this review.
TypeArticle
URIhttp://hdl.handle.net/1822/15303
DOI10.1021/bm200658b
ISSN1525-7797
Publisher versionhttp://pubs.acs.org/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:DET/2C2T - Artigos em revistas internacionais com arbitragem científica

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