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|Title: ||Synthesis of 3-indolylazoles and meridianin derivatives from indolyl enaminonitriles|
|Authors: ||Campos, Ana M. F. Oliveira|
Salaheldin, Abdellatif M.
Paz, Filipe A. Almeida
Rodrigues, Lígia M.
|Issue date: ||29-Nov-2011|
|Publisher: ||ARKAT-USA, Inc.|
|Abstract: ||The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5´-cyanomeridianin analogues (4). The same intermediate reacted with p-methoxyphenylhydrazine to give the pyrazolyl derivative (8).
Treatment of (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate (3a) with hydroxylamine hydrochloride in basic medium afforded (5-amino-isoxazol-4-yl)-(1H-indol-3-yl)-methanone (5) and the acrylic acid derivative (6) after a short or a long heating, respectively. Unequivocal structural elucidation of the latter compound was achieved from single-crystal X-ray diffraction studies.|
|Publisher version: ||http://www.arkat-usa.org/|
|Appears in Collections:||CDQuim - Artigos (Papers)|
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