Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/15059

Full metadata record
DC FieldValueLanguage
dc.contributor.authorAraújo, Ana Paula-
dc.contributor.authorCosta, Bruno Marques-
dc.contributor.authorCorreia, Ana L. Pinto-
dc.contributor.authorFragoso, Maria-
dc.contributor.authorFerreira, Paula-
dc.contributor.authorRibeiro, Mário Dinis-
dc.contributor.authorCosta, Sandra Maria Araújo da-
dc.contributor.authorReis, R. M.-
dc.contributor.authorMedeiros, Rui-
dc.date.accessioned2011-12-12T15:55:59Z-
dc.date.available2011-12-12T15:55:59Z-
dc.date.issued2011-01-28-
dc.date.submitted2010-01-26-
dc.identifier.issn1007-9327por
dc.identifier.urihttp://hdl.handle.net/1822/15059-
dc.description.abstractTo investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.por
dc.description.sponsorshipAstraZeneca Foundationpor
dc.description.sponsorshipThe Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte)por
dc.language.isoengpor
dc.publisherBaishideng Publishing Grouppor
dc.rightsopenAccesspor
dc.subjectEpidermal growth factor polymorphismpor
dc.subjectEpidermalpor
dc.subjectGastric cancerpor
dc.subjectEpidermal growth factor receptorpor
dc.titleAssociation between EGF +61A/G polymorphism and gastric cancer in Caucasianspor
dc.typearticlepor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.wjgnet.com/1007-9327/full/v17/i4/488.htmpor
sdum.publicationstatuspublishedpor
oaire.citationStartPage488por
oaire.citationEndPage492por
oaire.citationIssue4por
oaire.citationTitleWorld Journal of Gastroenterologypor
oaire.citationVolume17por
dc.identifier.doi10.3748/wjg.v17.i4.488por
dc.identifier.pmid21274378por
sdum.journalWorld Journal of Gastroenterologypor
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
2011_Araujo_A01_WJournGastr.pdfDocumento principal734,26 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID