Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/15059
Título: | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians |
Autor(es): | Araújo, Ana Paula Costa, Bruno Marques Correia, Ana L. Pinto Fragoso, Maria Ferreira, Paula Ribeiro, Mário Dinis Costa, Sandra Maria Araújo da Reis, R. M. Medeiros, Rui |
Palavras-chave: | Epidermal growth factor polymorphism Epidermal Gastric cancer Epidermal growth factor receptor |
Data: | 28-Jan-2011 |
Editora: | Baishideng Publishing Group |
Revista: | World Journal of Gastroenterology |
Resumo(s): | To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/15059 |
DOI: | 10.3748/wjg.v17.i4.488 |
ISSN: | 1007-9327 |
Versão da editora: | http://www.wjgnet.com/1007-9327/full/v17/i4/488.htm |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
2011_Araujo_A01_WJournGastr.pdf | Documento principal | 734,26 kB | Adobe PDF | Ver/Abrir |