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TitleAssociation between EGF +61A/G polymorphism and gastric cancer in Caucasians
Author(s)Araújo, Ana Paula
Costa, Bruno Marques
Correia, Ana L. Pinto
Fragoso, Maria
Ferreira, Paula
Ribeiro, Mário Dinis
Costa, Sandra Maria Araújo da
Reis, R. M.
Medeiros, Rui
KeywordsEpidermal growth factor polymorphism
Gastric cancer
Epidermal growth factor receptor
Issue date28-Jan-2011
PublisherBaishideng Publishing Group
JournalWorld Journal of Gastroenterology
Abstract(s)To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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