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TitleLab-on-a-chip with β-poly(vinylidene fluoride) based acoustic microagitation
Author(s)Cardoso, Vanessa Fernandes
Catarino, Susana Oliveira
Nunes, J. Serrado
Rebouta, L.
Rocha, J. G.
Lanceros-Méndez, S.
Minas, Graça
KeywordsAcoustic microagitation
Indium tin oxide (ITO)
β-poly(vinylidene fluoride) (β-PVDF)
beta-poly(vinylidene fluoride) (beta-PVDF)
Issue dateMay-2010
JournalIeee Transactions on Biomedical Engineering
Abstract(s)This paper reports a fully integrated disposable labon- a-chip with acoustic microagitation based on a piezoelectric β-poly(vinylidene fluoride) (β-PVDF) polymer. The device can be used for the measurement, by optical absorption spectroscopy, of biochemical parameters in physiological fluids. It comprises two dies: the fluidic die that contains the reaction chambers fabricated in SU-8 and the β-PVDF polymer deposited underneath them; and the detection die that contains the photodetectors, its readout electronics, and the piezoelectric actuation electronics, all fabricated in a CMOS microelectronic process. The microagitation technique improves mixing and shortens reaction time. Further, it generates heating, which also improves the reaction time of the fluids. In this paper, the efficiency of the microagitation system is evaluated as a function of the amplitude and the frequency of the signal actuation. The relative contribution of the generated heating is also discussed. The system is tested for the measurement of the uric acid concentration in urine.
AccessRestricted access (UMinho)
Appears in Collections:DEI - Artigos em revistas internacionais

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