Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/14415

TitleStudy of the fosfosal controlled permeation through glutaraldehyde crosslinked chitosan membranes
Author(s)Silva, R. M.
Mano, J. F.
Reis, R. L.
KeywordsChitosan
Drug release
Fosfosal
Diffusion cell
Biodegradable
Glutaraldehyde
Issue date2006
PublisherTrans Tech Publications
JournalMaterials Science Forum
Abstract(s)Fosfosal, a phosphate derivative of salicylic acid, which presents both analgesic and antiinflammatory properties, was used as a model drug to study the potential of recently developed chitosan membranes (with different crosslinking degrees) to be used as drug release rate-controlling membranes. The fosfosal permeation across these membranes was studied using an in-house built developed diffusion cell with online automatic monitoring. Experiments were performed using phosphate buffer saline (PBS) solution at 37ºC. Different flow properties of the detection set up were determined in order to estimate the errors introduced by the automatic online monitoring system. For increasing crosslinking degrees the permeability initially decreased, and then increased, likely as a consequence of the crosslinking influence on a variety of properties like crystallinity and hydrophilicity that have opposite influence on permeability. In summary, it was possible to control the drug release profile by means of changing the degree of crosslinking of chitosan membranes and to follow the respective release kinetics by means of using the developed diffusion cell
TypeConference paper
DescriptionAdvanced material forum III : proceedings of the III International Materials Symposium, Aveiro, 2005
URIhttp://hdl.handle.net/1822/14415
ISBN*************
ISSN1662-9752
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Publicações em atas de conferências - indexadas no ISI Web of Science

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