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TitleInjectable biodegradable starch/chitosan delivery system for the sustained release of gentamicin to treat bone infections
Author(s)Balmayor, Elizabeth Rosado
Baran, E. T.
Azevedo, Helena S.
Reis, R. L.
KeywordsStarch-conjugated chitosan
Sustained release
Staphylococcus aureus
Issue date2012
JournalCarbohydrate Polymers
Abstract(s)Starch-conjugated chitosan microparticles were produced aimed to be used as a carrier for the long term sustained/controlled release of antibiotic drugs to control bone infection. The microparticles were prepared by a reductive alkylation crosslinking method. The obtained microparticles showed a spherical shape, with a slightly rough and porous surface, and a size range of 80–150 μm. Gentamicin was entrapped into the starch-conjugated chitosan microparticles and its release profile was studied in vitro. Increasing concentrations of gentamicin (from 50 to 150 mg/mL) led to a decrease in the encapsulation efficiency (from 67 to 55%), while drug loading increased from 4 to 27%. A sustained release of gentamicin was observed over a period of 30 days. The release kinetics could be controlled using an ionic crosslinker agent. In addition, a bacterial inhibition test on Staphylococcus aureus shows a diameter of the sample inhibition zone ranging from 12 to 17 mm (70–100% of relative activity).
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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