Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14303
Título: | Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
Autor(es): | Sá, Arsénio Vasconcelos Matias, Áurea A. Prata, M. Isabel M. Geraldes, Carlos F. G. C. Ferreira, Paula M. T. André, João P. |
Palavras-chave: | Triaza Orthogonal protection Bifunctional chelators Gallium Radiopharmacy Integrin αѵβ₃receptor Integrin alpha(v)beta(3) receptor Integrin a ß receptor ? 3 Integrin α β receptor ν 3 |
Data: | 2010 |
Editora: | Elsevier |
Revista: | Bioorganic and Medicinal Chemistry Letters |
Resumo(s): | We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/14303 |
DOI: | 10.1016/j.bmcl.2010.10.059 |
ISSN: | 0960-894X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Gallium_labeled_NOTA-based_conjugates_Revised_V3.pdf | 726,68 kB | Adobe PDF | Ver/Abrir |