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TitleBone regenerative properties of injectable PGLA-CaP composite with TGF-beta1 in a rat augmentation model.
Author(s)Plachokova, A.
Link, Dennis P.
Van den Dolder, Juliette
Van den Beucken, Jeroen J.
Jansen, John A.
Injectable CaP cement
PGLA–CaP composite
Bone augmentation
Issue date2007
JournalJournal of Tissue Engineering and Regenerative Medicine
Abstract(s)The aim of this study was to examine the bone augmentation properties of an injectable composite consisting of PLGA microspheres/CaP cement (20/80), and the additional effect of loading PLGA microspheres with TGF-β1 (200 ng). For this purpose, PLGA/CaP composites (control) and PLGA/CaP composites loaded with TGF-β1 (test group) were injected on top of the skulls of 24 Wistar rats. Each rat received 2 materials from the same experimental group, and in total 48 implants were placed (n = 8). After 2, 4, and 8 weeks the results were evaluated histologically and histomorphometrically. The contact length between the implants and newly formed bone increased in time, and was significantly higher for the TGF-β1-loaded composites after 2 weeks. Also, bone formation was significantly higher for the TGF-β1-loaded composites (18.5% ± 3) compared to controls (7.21% ± 5) after 8 weeks of implantation. Immunohistochemical staining demonstrated massive inflammatory infiltrates in both groups, particularly at 2 weeks, which decreased substantially at 4 and 8 weeks. In conclusion, injectable PLGA/CaP composites stimulated bone augmentation in a rat model. The addition of TGF-β1 to the composite significantly increased bone contact at 2 weeks and enhanced new bone formation at 8 weeks.
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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