Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/14187

TitlePreparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs
Author(s)Duarte, Ana Rita C.
Costa, M. S.
Simplicio, A. L.
Cardoso, M. Margarida
Duarte, Catarina M. M.
KeywordsControlled delivery systems
Supercritical fluids
SAS
Ethylcellulose
Anti-inflammatory drugs
Issue date2006
PublisherElsevier
JournalInternational Journal of Pharmaceutics
Abstract(s)Ethylcellulose/methylcellulose blends were produced using different precipitation techniques and impregnated with naproxen, a non-steroidal anti-inflammatory drug (NSAID). Solvent-evaporation technique was used not only for the preparation of ethylcellulose/methylcellulose microspheres but also to encapsulate naproxen. Supercritical fluid (SCF) impregnation was also performed to prepare naproxen loaded microspheres. The microspheres, impregnated by the SCF technique, were prepared both by solvent-evaporation and by a supercritical antisolvent (SAS) process. In vitro release profiles at pH 7.4 and 1.2, of naproxen-loaded microspheres were evaluated and the results were modelled Fick’s law of diffusion and Power law. Miscrospheres prepared by supercritical antisolvent have a higher loading capacity and present a slower release profile. The systems studied present a release mechanism controlled by drug diffusion which complies Fick’s law of diffusion.
TypeArticle
URIhttp://hdl.handle.net/1822/14187
ISSN0378-5173
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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