Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14141
Título: | Genipin modified silk fibroin nanometric-nets |
Autor(es): | Silva, Simone Santos Maniglio, D. Motta, A. Mano, J. F. Reis, R. L. Migliaresi, C. |
Palavras-chave: | Biofibers Electrospinning Genipin Modification Silk fibroin |
Data: | Ago-2008 |
Editora: | Wiley |
Revista: | Macromolecular Bioscience |
Resumo(s): | Nanometric silk-fibroin nets were fabricated by electrospinning from regenerated Bombyx mori silk-fibroin (SF)/formic acid solutions with the addition of genipin (GE), 2, 15 and 24 h after the solution preparation. After spinning, the pure fibroin nanofibers were water soluble and needed a further stabilization process, whereas the reaction of fibroin with genipin resulted in water-insoluble fibroin nets due to conformational changes induced in the fibroin by the genipin. SFGE nanofibers presented diameters ranging from 140 to 590 nm and were generally thinner than pure SF nanofibers. The secondary structure of SF into SFGE nanofibers showed the presence of a β-sheet conformation together with β-turn intermediates (turns and bends). The approach described in this paper provides an alternative method of designing SF nanofibers that are already water insoluble, without any stability post-treatment needed. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/14141 |
DOI: | 10.1002/mabi.200700300 |
ISSN: | 1616-5195 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |