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TitlePreparation of ethylcellulose/methylcellulose blends by supercritical antisolvent precipitation
Author(s)Duarte, Ana Rita C.
Gordillo, M. D.
Cardoso, M. Margarida
Simplicio, A. L.
Duarte, Catarina M. M.
KeywordsBiocompatible polymers
Supercritical fluid antisolvent (SAS)
Release systems
Issue date2006
JournalInternational Journal of Pharmaceutics
Abstract(s)The supercritical antisolvent (SAS) techniquewas used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40 ◦C and 80 bar.
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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