Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/14001

TitleBone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
Author(s)Bessa, Paulo C.
Casal, Margarida
Reis, R. L.
KeywordsBone morphogenetic proteins
Delivery carriers
Polymers
Biomaterials
Clinical uses
Tissue engineering
Issue date2008
PublisherWiley
JournalJournal of Tissue Engineering and Regenerative Medicine
Abstract(s)Bone morphogenetic proteins (BMPs) are cytokines with a strong effect on bone and cartilage growth and with important roles during embryonic patterning and early skeletal formation. BMPs have promising potential for clinical bone and cartilage repair, working as powerful boneinducing components in diverse tissue-engineering products. Synthetic polymers, natural origin polymers, inorganic materials and composites may be used as carriers for the delivery of BMPs. Carriers range from nanoparticles to complex three-dimensional (3D) scaffolds, membranes for tissue-guided regeneration, biomimetic surfaces and smart thermosensitive hydrogels. Current clinical uses include spinal fusion, healing of long bone defects and craniofacial and periodontal applications, amongst others. BMP-2 and BMP-7 have recently received approval by the US Food and Drug Administration (FDA) for specific clinical cases, delivered in absorbable collagen sponges. Considering the expanding number of publications in the field of BMPs, there are prospects of a brilliant future in the field of regenerative medicine of bone and cartilage with the use of BMPs.
TypeArticle
URIhttp://hdl.handle.net/1822/14001
DOI10.1002/term.74
ISSN1932-7005
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
file.pdf208,67 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID