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https://hdl.handle.net/1822/13491| Título: | Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi IPN beads |
| Autor(es): | Shi, Jun Alves, N. M. Mano, J. F. |
| Palavras-chave: | Alginate Biomaterials Drug delivery systems PH/temperature responsive |
| Data: | 2006 |
| Editora: | Wiley-Blackwell |
| Revista: | Macromolecular Bioscience |
| Resumo(s): | A series of semi-interpenetrating, polymer network (semi-IPN), hydrogel beads, composed of calcium alginate (Ca-alginate) and poly(N-isopropylacrylamide) (PNIPAAM), were prepared for a pH/temperature-sensitive drug delivery study. The equilibrium swelling showed the independent pH- and thermo- responsive nature of the developed materials. At pH¼2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH¼7.4. The release rate of the drug was higher at 37 8Cthan that at 25 8C and increased slightly with increasing PNIPAAM content. These results suggest that the Caalginate/ PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents. |
| Tipo: | Artigo |
| URI: | https://hdl.handle.net/1822/13491 |
| DOI: | 10.1002/mabi.200600013 |
| ISSN: | 1616-5187 |
| Arbitragem científica: | yes |
| Acesso: | Acesso aberto |
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