Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/13424

TitleSupercritical antisolvent precipitation of PHBV microparticles
Author(s)Costa, M. S.
Duarte, Ana Rita C.
Cardoso, M. M.
Duarte, Catarina M. M.
KeywordsSupercritical fluids
Micronization
SAS
Natural polymers
PHBV
Drug delivery
Issue date2007
PublisherElsevier
JournalInternational Journal of Pharmaceutics
Abstract(s)The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SASexperiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 mwere obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 ◦C, 100 bar, 1mLmin−1 liquid flow and 10 L min−1 carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased.
TypeArticle
URIhttp://hdl.handle.net/1822/13424
ISSN0378-5173
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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