Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/13090
Título: | Novel DNA fluorescence probes based on N-[5-(11-functionalised-undecylamino)-9H-benzo[a]phenoxazin-9-ylidene]propan-1-aminium chlorides: synthesis and photophysical studies |
Autor(es): | Alves, Carla M. A. Naik, Sarala Coutinho, Paulo J. G. Gonçalves, M. Sameiro T. |
Palavras-chave: | Benzo[a]phenoxazinium dyes Nile blue DNA probes Near-infrared fluorophores Functionalised probes |
Data: | Jan-2011 |
Editora: | Elsevier |
Revista: | Tetrahedron Letters |
Resumo(s): | Fluorescent benzo[a]phenoxazinium chlorides possessing undecylamino chains with functionalised ending-groups (hydroxyl, carboxylic acid and the ester group) as substituents at the 5-position of the heterocycles were successfully synthesised and characterised. These compounds were used in photophysical studies with DNA, and compared to the corresponding analogue with a non-functionalised terminal (methyl group). It was found that the functionalised terminal exerts a dramatic influence on the type of interaction with the hydroxyl group promoting intercalation, while the ester group promotes groove binding. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/13090 |
DOI: | 10.1016/j.tetlet.2010.10.165 |
ISSN: | 0040-4039 |
Versão da editora: | http://www.sciencedirect.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDF - FAMO - Artigos/Papers (with refereeing) CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Tet Lett 2011.pdf | Final draft post-refereeing | 969,44 kB | Adobe PDF | Ver/Abrir |