Please use this identifier to cite or link to this item:

TitleThe influence of patterned nanofiber meshes on human mesenchymal stem cell osteogenesis
Author(s)Martins, Albino
Silva, Marta L. Alves da
Faria, Susana
Marques, A. P.
Reis, R. L.
Neves, N. M.
Mesenchymal stem cells
Patterned nanofiber meshes
Tissue engineering
Issue date1-Jul-2011
JournalMacromolecular Bioscience
Abstract(s)A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an autologous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under basal and osteogenic differentiation conditions. The microtopography of the P-NFM also controls the deposition of mineralized extracellular matrix along the pre-defined fiber direction. Genotypic characterization confirms the successful differentiation into the osteogenic lineage.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cells Osteogenesis - Martins A, ..., Neves NM.pdfAMartins_Macromolecular Bioscience 2011965,06 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID