Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/12931

TitleThe influence of patterned nanofiber meshes on human mesenchymal stem cell osteogenesis
Author(s)Martins, Albino
Silva, Marta L. Alves da
Faria, Susana
Marques, A. P.
Reis, R. L.
Neves, N. M.
KeywordsBiodegradable
Electrospinning
Mesenchymal stem cells
Patterned nanofiber meshes
Tissue engineering
Issue date1-Jul-2011
PublisherWiley
JournalMacromolecular Bioscience
Abstract(s)A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an autologous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under basal and osteogenic differentiation conditions. The microtopography of the P-NFM also controls the deposition of mineralized extracellular matrix along the pre-defined fiber direction. Genotypic characterization confirms the successful differentiation into the osteogenic lineage.
TypeArticle
URIhttp://hdl.handle.net/1822/12931
DOI10.1002/mabi.201100012
ISSN1616-5187
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/mabi.201100012/abstract
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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