Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/12931
Título: | The influence of patterned nanofiber meshes on human mesenchymal stem cell osteogenesis |
Autor(es): | Martins, Albino Silva, Marta L. Alves da Faria, Susana Marques, A. P. Reis, R. L. Neves, N. M. |
Palavras-chave: | Biodegradable Electrospinning Mesenchymal stem cells Patterned nanofiber meshes Tissue engineering |
Data: | 1-Jul-2011 |
Editora: | Wiley |
Revista: | Macromolecular Bioscience |
Resumo(s): | A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an autologous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under basal and osteogenic differentiation conditions. The microtopography of the P-NFM also controls the deposition of mineralized extracellular matrix along the pre-defined fiber direction. Genotypic characterization confirms the successful differentiation into the osteogenic lineage. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/12931 |
DOI: | 10.1002/mabi.201100012 |
ISSN: | 1616-5187 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201100012/abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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The Influence of Patterned Nanofiber Meshes on Human Mesenchymal Stem Cells Osteogenesis - Martins A, ..., Neves NM.pdf | AMartins_Macromolecular Bioscience 2011 | 965,06 kB | Adobe PDF | Ver/Abrir |